As someone who has lived in Prague for some time I would love to share with you a few quick tips on what to do in this lovely city. I can honestly say I have yet to live in a better city (within Europe)... and trust me when I say I have lived in many, many, many places. So what's the secret? Well, I wont go into detail here and leave some room for you to explore and to establish your own opinion.
One TIP to keep in mind when in Prague:
Blend in! become a local, assimilate, get weird, be authentic, find a true local and have her / him show you around. This tip should hold true for all your travels. not just this one.
If you truly do not have a clue where to start and you are tired of reading random tips and guides then give my custom picked & local itinerary a try. Don't forget to leave feedback if you do!
OFF YOU GO!
My local 1 day walkable guide to Prague (links point to Google Maps):
Start at Wenceslas Square super early in the morning. While here check out the square but do not waste too much time here as you are in for way better things
From here walk to Namesti Miru which is in Vinohrady (a place where all the hip and cool people live in Prague a.k.a the young millennials).
From Namesti Miru walk down "Anglicka" street to a small roundabout in the middle of the street called Kasna. This walk will take you through some nice local historic living quarter streets.
Then walk down the street all the way till you make it to Bastion. This is a hip restaurant on top of the city fortress wall. Have a proseco or mimosa here to strengthen you for what is yet to come. .
From here walk around the fortress walls and get playful with your photos of the views ;). Your goal is to make it across the valley to the other side to a church called Vysehrad. A lot of trails lead there so pick one.
While at Vysehrad check out the views, the church, and the old cemetary (if you are into this kind of stuff...).
Then walk down to the water front to eat lunch at a place called Naplavka. This is a popular waterfront market full of food pop up stands and beer stands. If you are a Vegan then there is a also a great place for you to eat at called Herbivore.
Keep walking up north (towards the castle) along the river until you hit "Narodni" street. Here take a left and check out Strelecky ostrov.